AADAT
Description
The AADAT (aminoadipate aminotransferase) is a protein-coding gene located on chromosome 4.
The AADAT gene encodes a mitochondrial enzyme known as Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, or alpha-aminoadipate aminotransferase. This enzyme is responsible for converting alpha-aminoadipate to alpha-ketoadipate. It is also classified as one of the Kynurenine—oxoglutarate transaminases.
AADAT is a transaminase with broad substrate specificity. It catalyzes the transfer of an amino group from various amino acids, including aminoadipate, kynurenine, methionine, glutamate, tryptophan, aspartate, and hydroxykynurenine, to a variety of oxo-acids. It exhibits a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate, and alpha-oxo-gamma-methiol butyric acid as amino-group acceptors. Additionally, AADAT can use glyoxylate as an amino-group acceptor in vitro.
AADAT is also known as KAT2, KATII, KYAT2.
