A1BG-AS1

The A1BG-AS1 gene is an RNA gene that falls into the long non-coding RNA (lncRNA) class. Here are some key details about A1BG-AS1:

Gene Symbol: A1BG-AS1
Aliases: A1BG Antisense RNA 1, NCRNA00181, FLJ23569, and more 1.
Function: As an lncRNA, its precise function remains unclear.
Genomic Location: Chromosome 19 (GRCh38/hg38: 58,346,400-58,349,001; GRCh37/hg19: 58,857,766-58,860,367)1.

Disease Associations:

Liver Cancer: A1BG-AS1 is downregulated in liver cancer and associated with prognostic features such as microvascular infiltration, advanced tumor staging, high tumor grade, and poor clinical outcomes 2.
Breast Cancer: In breast cancer tissues and cell lines, A1BG-AS1 is highly expressed. Depletion of A1BG-AS1 suppresses cell proliferation, accelerates apoptosis, and hinders migration and invasion. It also reduces tumor growth in vivo 3.

While more research is needed to fully understand its role, A1BG-AS1’s involvement in cancer progression highlights its potential significance. 🧬🔬

WES Whole Exome Sequencing

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