WNT10A : Wnt family member 10A
Description
The WNT10A (Wnt family member 10A) is a protein-coding gene located on chromosome 2.
The WNT10A gene is a member of the WNT gene family, which plays crucial roles in development before birth. These genes create proteins involved in chemical signaling pathways that control the activity of certain genes and regulate cell interactions during embryonic development. The WNT10A protein is essential for the formation of tissues derived from the ectoderm, including the skin, hair, nails, teeth, and sweat glands. It plays a particularly important role in the formation and shaping of both baby and adult teeth.
WNT10A protein is a ligand for members of the frizzled family of seven transmembrane receptors. It functions in the canonical Wnt/beta-catenin signaling pathway. It is essential for normal ectoderm development, including the formation of teeth, tongue papillae, sweat ducts, hair follicles, and plantar epithelium. WNT10A is required for normal proliferation of basal cells in these tissues and for the expression of keratins in tongue papillae and KRT9 in foot plantar epithelium. WNT10A forms a soluble 1:1 complex with AFM, which prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids.
WNT10A is also known as ECTD16, OODD, SSPS, STHAG4.
Associated Diseases
- Odontoonychodermal dysplasia
- Schöpf-Schulz-Passarge syndrome
- Tooth agenesis, selective, 4
- Oligodontia
- Schopf-Schulz-Passarge syndrome
- Autosomal recessive hypohidrotic ectodermal dysplasia
- Hypohidrotic ectodermal dysplasia
- Keratoconus
