WIPF1
Description
The WIPF1 (WAS/WASL interacting protein family member 1) is a protein-coding gene located on chromosome 2.
WIPF1 encodes a protein that is vital for organizing the actin cytoskeleton. Increasing the amount of WIP in cells leads to more actin polymerization. The protein binds to a specific part of Wiskott–Aldrich syndrome protein (WASp), a region often mutated in Wiskott–Aldrich syndrome, an X-linked genetic disorder. Problems with the interaction between WIPF1 and WASp could contribute to the disease. Two versions of the gene's instructions, both making the same protein, have been found. If someone lacks the WIPF1 gene, WASp levels decrease, and they experience WAS symptoms. WIPF1 interacts with several other proteins, including WASp, N-WASp, Cortactin, NCK1, MYO1e, and ITSN1. While WASp is only found in blood-forming cells, WIPF1 is found throughout the body. Most of the mutations causing Wiskott Aldrich Syndrome are found within the WH1 domain of WASp.
WIPF1 plays a crucial role in reorganizing the actin cytoskeleton. It collaborates with NCK1 and GRB2 to recruit and activate WASL, potentially influencing the subcellular localization of WASL. This may lead to the breakdown of stress fibers and the formation of filopodia. WIPF1 is also implicated in the formation of cell ruffles and plays a significant role in the intracellular motility of vaccinia virus by acting as an adapter that recruits WASL to the virus.
WIPF1 is also known as PRPL-2, WAS2, WASPIP, WIP.
