WDR35 : WD repeat domain 35

Description

The WDR35 (WD repeat domain 35) is a protein-coding gene located on chromosome 2.

The WDR35 gene provides instructions for making a protein essential for the formation and maintenance of cilia, microscopic, finger-like projections crucial for cell signaling. Cilia are vital for the development and function of various tissues, including kidneys, liver, and the retina. They also contribute to bone development, although the mechanism is not fully understood. WDR35 is part of the IFT-A complex involved in intraflagellar transport, a process that uses IFT particles to move materials within cilia. This complex carries materials from the tip to the base of cilia, playing a critical role in regulating the Sonic Hedgehog signaling pathway, which governs cell growth, maturation, and body shaping, especially during embryonic development.

WDR35, as part of the IFT complex A (IFT-A), plays a crucial role in retrograde ciliary transport, facilitating the entry of G protein-coupled receptors (GPCRs) into cilia. This involvement makes it essential for ciliogenesis and the trafficking of proteins within cilia. Additionally, WDR35 might promote CASP3 activation and apoptosis triggered by TNF.

WDR35 is also known as CED2, CFAP118, FAP118, IFT121, IFTA1, SRTD7.

Associated Diseases

Comprehensive carrier screening

WES Whole Exome Sequencing

Clinical Exome Sequencing