VPS11

Description

The VPS11 (VPS11 core subunit of CORVET and HOPS complexes) is a protein-coding gene located on chromosome 11.

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.

== Function == Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.

== Interactions == VPS11 has been shown to interact with VPS18, VPS33A and STX7.

VPS11 plays a crucial role in vesicle-mediated protein trafficking to lysosomal compartments, encompassing both endocytic membrane transport and autophagic pathways. It is thought to serve as a core component of the putative HOPS and CORVET endosomal tethering complexes. These complexes are believed to be involved in the transition from early to late endosomes, likely through the Rab5-to-Rab7 endosome conversion, potentially implicating MON1A/B. VPS11's interaction with SNAREs and SNARE complexes mediates tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is thought to be recruited to Rab7 on the late endosomal membrane and regulates late endocytic, phagocytic, and autophagic traffic towards lysosomes. Conversely, the CORVET complex is proposed to function as a Rab5 effector, facilitating early endosome fusion, potentially within specific endosome subpopulations. VPS11 is essential for the fusion of endosomes and autophagosomes with lysosomes and participates in cargo transport from early to late endosomes. Notably, it plays a role in the retrograde Shiga toxin transport.

VPS11 is also known as END1, HLD12, HLD12; DYT32, PEP5, RNF108, hVPS11.

Associated Diseases

• Leukodystrophy, hypomyelinating, 12
• Dystonia 32
• VPS11-related autosomal recessive hypomyelinating leukodystrophy