TXNRD2
Description
TXNRD2, also known as thioredoxin reductase 2, is a crucial enzyme involved in maintaining cellular redox homeostasis. It catalyzes the reduction of thioredoxin, a small protein that plays a critical role in reducing oxidative stress and protecting cells from damage. TXNRD2 is primarily located in mitochondria, the powerhouses of cells, where it safeguards against reactive oxygen species (ROS) production and ensures proper mitochondrial function. Its activity is essential for various cellular processes, including DNA replication, protein synthesis, and apoptosis.
Associated Diseases
- Cardiovascular Diseases: TXNRD2 dysfunction is linked to heart failure and atherosclerosis.
- Neurodegenerative Diseases: Reduced TXNRD2 activity is associated with Alzheimer‘s disease and Parkinson‘s disease.
- Cancer: Aberrant TXNRD2 expression is implicated in various cancer types, influencing tumor growth and metastasis.
- Diabetes: TXNRD2 plays a role in insulin sensitivity and pancreatic beta-cell function.
Did you know?
TXNRD2 is a key player in the cellular response to oxidative stress, which is implicated in aging and various diseases.
