TSHB : thyroid stimulating hormone subunit beta
Description
The TSHB gene, provides instructions for making the beta subunit of thyroid-stimulating hormone (TSH). TSH, produced by the pituitary gland, plays a crucial role in regulating thyroid hormone production. It binds to receptors on thyroid cells, stimulating the release of thyroxine (T4) and triiodothyronine (T3), essential hormones for growth, metabolism, and overall development. The TSHB gene‘s function is critical for maintaining proper thyroid function.
Associated Diseases
- Hypothyroidism: Deficiency in TSH production can lead to hypothyroidism, causing fatigue, weight gain, and slowed metabolism.
- Hyperthyroidism: Rarely, mutations in the TSHB gene can result in excess TSH production, leading to hyperthyroidism, characterized by hyperactivity, weight loss, and increased metabolism.
- Congenital Hypothyroidism: Mutations in the TSHB gene can cause congenital hypothyroidism, a condition present at birth, where thyroid hormone production is insufficient.
Did you know?
The beta subunit of TSH is unique to this hormone, while the alpha subunit is shared with other hormones like luteinizing hormone and follicle-stimulating hormone.
