TSEN15
Description
The TSEN15 (tRNA splicing endonuclease subunit 15) is a protein-coding gene located on chromosome 1.
TSEN15 is a gene that encodes for the tRNA-splicing endonuclease subunit Sen15, an enzyme essential for tRNA splicing. tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the initial step in tRNA splicing. TSEN15 has been shown to interact with C1orf19.
TSEN15, also known as SEN15 homolog, is a non-catalytic subunit of the tRNA-splicing endonuclease complex. This complex is responsible for identifying and cleaving splice sites within pre-tRNA molecules. Specifically, TSEN15 participates in the cleavage of pre-tRNA at the 5' and 3' splice sites, releasing the intron and generating two tRNA half-molecules. These half-molecules possess 2',3' cyclic phosphate and 5'-OH termini. The splice sites lack conserved sequences, but the intron consistently occupies the same position within the gene, maintaining a fixed distance from the tRNA body's structural features. Notably, the tRNA splicing endonuclease also participates in mRNA processing through its interaction with pre-mRNA 3'-end processing factors. This association links pre-tRNA splicing to pre-mRNA 3'-end formation, suggesting that TSEN15 and other endonuclease subunits play roles in multiple RNA-processing events.
TSEN15 is also known as C1orf19, PCH2F, sen15.
