TRIP13 : thyroid hormone receptor interactor 13

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Description

TRIP13, also known as katanin p60 subunit A, is a crucial gene involved in the regulation of microtubule dynamics during cell division. It encodes a protein that forms part of a complex responsible for severing microtubules, a process essential for proper chromosome segregation and cell cycle progression. TRIP13 plays a critical role in ensuring accurate duplication of genetic material and preventing errors that can lead to genomic instability and cancer. Its deregulation has been implicated in various cancers, highlighting its significance in tumorigenesis.

Associated Diseases

• Cancer (particularly breast cancer, lung cancer, and colorectal cancer)
• Neurodevelopmental disorders (e.g., autism spectrum disorder)
• Developmental abnormalities (e.g., microcephaly)

Did you know?

TRIP13‘s name derives from its role in "TRIPping" microtubules, as it severs them, leading to changes in their structure and function.