TRIM36
Description
TRIM36, a gene encoding a protein involved in the ubiquitin-proteasome system, plays a crucial role in maintaining cellular homeostasis. It acts as a molecular chaperone, aiding in the proper folding and degradation of proteins. TRIM36 also participates in immune responses, contributing to the regulation of inflammation and antiviral defense. Its dysfunction can disrupt cellular processes, leading to various diseases.
Associated Diseases
- Neurodegenerative diseases (e.g., Parkinson‘s disease, Alzheimer‘s disease)
- Cancer (e.g., leukemia, breast cancer)
- Immune disorders (e.g., autoimmune diseases)
- Developmental disorders (e.g., intellectual disability)
Did you know?
TRIM36 exhibits a unique structural feature called a RING domain, which is essential for its ubiquitin ligase activity. This domain allows TRIM36 to attach ubiquitin tags to target proteins, marking them for degradation.
