TNFSF11
Description
The TNFSF11 gene, encodes for the protein RANKL (receptor activator of nuclear factor kappa-B ligand). RANKL is a key regulator of osteoclastogenesis, the process of bone resorption. It interacts with its receptor, RANK, on the surface of osteoclast precursors, initiating a signaling cascade that leads to their differentiation and activation. This intricate interplay between RANKL and RANK is crucial for maintaining bone homeostasis, where bone formation and resorption are balanced.
Associated Diseases
- Osteoporosis: Reduced bone density due to increased bone resorption.
- Paget‘s Disease of Bone: Disorder characterized by excessive bone breakdown and disorganized bone formation.
- Multiple Myeloma: Cancer of plasma cells that often leads to bone lesions.
- Inflammatory Bowel Disease: RANKL has been implicated in the pathogenesis of inflammatory bowel diseases like Crohn‘s disease.
- Rheumatoid Arthritis: RANKL is involved in the bone destruction observed in rheumatoid arthritis.
- Cancer Metastasis: Increased RANKL expression has been linked to tumor growth and metastasis in various cancers.
Did you know?
RANKL is also involved in the immune system, playing a role in T-cell activation and the development of lymph nodes.
