TNFRSF4
Description
The TNFRSF4 gene, encoding the protein OX40 (also known as CD134 or TNFRSF4), plays a crucial role in regulating immune responses. This gene belongs to the tumor necrosis factor receptor superfamily (TNFRSF), a group of transmembrane proteins involved in diverse cellular processes, including inflammation, apoptosis, and cell survival. OX40 is primarily expressed on activated T cells, where it interacts with its ligand, OX40L, expressed on antigen-presenting cells. This interaction initiates signaling cascades that promote T cell proliferation, survival, and differentiation into effector T cells, thereby contributing to the development of immune responses. OX40 signaling is essential for optimal T cell-mediated immunity, but it can also contribute to the pathogenesis of various diseases.
Associated Diseases
- Autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis)
- Infectious diseases (e.g., viral infections, bacterial infections)
- Cancer (e.g., lymphoma, melanoma)
- Allergies
- Graft-versus-host disease
Did you know?
OX40 signaling has been shown to be involved in the generation of memory T cells, which are long-lived immune cells that can quickly respond to subsequent encounters with the same pathogen.
