TNFRSF11B : TNF receptor superfamily member 11b

Description

The TNFRSF11B gene, also known as the receptor activator of nuclear factor kappa-B (RANK), encodes a transmembrane protein crucial for immune system development and function. This protein plays a pivotal role in osteoclast differentiation, a process essential for bone remodeling. TNFRSF11B also participates in various biological processes, including inflammation, angiogenesis, and cancer development. Understanding the complex functions of this gene is crucial for developing targeted therapies for diseases like osteoporosis, inflammatory disorders, and certain cancers.

Associated Diseases

• Osteoporosis
• Osteopetrosis
• Paget's disease of bone
• Multiple myeloma
• Breast cancer
• Prostate cancer
• Lung cancer
• Rheumatoid arthritis
• Crohn's disease

Did you know?

Mutations in TNFRSF11B are associated with rare genetic disorders, such as osteopetrosis, characterized by increased bone density due to impaired osteoclast function.