TNFRSF11A : TNF receptor superfamily member 11a
Description
The TNFRSF11A gene, also known as the receptor activator of nuclear factor kappa-B ligand (RANKL) gene, plays a crucial role in the immune system by regulating the differentiation, activation, and survival of osteoclasts, immune cells responsible for bone resorption. RANKL, the protein product of this gene, interacts with its receptor RANK (TNFRSF11A) on osteoclast precursors, initiating a signaling cascade that leads to osteoclast formation and bone breakdown. This process is tightly controlled to maintain bone homeostasis. Dysregulation of RANKL signaling can lead to various bone diseases, including osteoporosis, rheumatoid arthritis, and Paget‘s disease of bone.
Associated Diseases
- Osteoporosis
- Rheumatoid arthritis
- Paget‘s disease of bone
- Multiple myeloma
- Breast cancer
- Prostate cancer
Did you know?
The TNFRSF11A gene is also involved in the development of teeth and the regulation of immune responses in the gut.
