TGM5 : transglutaminase 5
Description
The TGM5 (transglutaminase 5) is a protein-coding gene located on chromosome 15.
The TGM5 gene provides instructions for making an enzyme called transglutaminase 5. This enzyme is found in many of the body's tissues, although it seems to play a key role in the outer layer of skin (the epidermis). In the epidermis, transglutaminase 5 is involved in the formation of a structure called the cornified cell envelope, which surrounds epidermal cells and helps the skin form a protective barrier between the body and its environment. Specifically, transglutaminase 5 forms strong bonds, called cross-links, between the structural proteins that make up the cornified cell envelope. This cross-linking provides strength and stability to the epidermis.
TGM5 is also known as PSS2, TG(X), TGASE5, TGASEX, TGM6, TGMX, TGX.
