TGM1 : transglutaminase 1
Description
TGM1, encodes the enzyme transglutaminase 1 (TG1), a key player in various biological processes. It‘s essential for tissue repair, wound healing, and the formation of the skin‘s protective barrier. TG1 acts as a ‘molecular glue‘, crosslinking proteins through a process called transamidation. This process strengthens tissues, stabilizes structures, and plays a crucial role in immune defense. TGM1 expression is tightly regulated, with variations contributing to both normal and pathological conditions.
Associated Diseases
- Celiac Disease: Autoimmune disorder triggered by gluten, where TGM1 is targeted by antibodies.
- Dermatitis Herpetiformis: A skin condition characterized by blistering and itching, linked to TGM1 autoimmunity.
- Epidermolysis Bullosa: A group of genetic disorders affecting the skin‘s structural integrity, some forms linked to TGM1 mutations.
- Cancer: TGM1 over-expression has been implicated in tumor growth and metastasis in various cancer types.
Did you know?
TG1 is used in the food industry to improve texture and extend the shelf life of certain foods.
