TGFB1
Description
The TGFB1 (transforming growth factor beta 1) is a protein-coding gene located on chromosome 19.
The TGFB1 gene provides instructions for producing a protein called transforming growth factor beta-1 (TGFβ-1). The TGFβ-1 protein triggers chemical signals that regulate various cell activities inside the cell, including the growth and division (proliferation) of cells, the maturation of cells to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis).The TGFβ-1 protein is found throughout the body but is particularly abundant in tissues that make up the skeleton, where it helps regulate the formation and growth of bone and cartilage, a tough, flexible tissue that makes up much of the skeleton during early development. TGFβ-1 is also involved in the formation of blood vessels, development of muscle tissue and body fat, wound healing, inflammatory processes in the immune system, and prevention of tumor growth.
Transforming growth factor beta-1 proprotein is the precursor to both the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains. LAP forms the regulatory subunit of TGF-beta-1, while TGF-beta-1 itself constitutes the active subunit.
TGFB1 is also known as CED, DPD1, IBDIMDE, LAP, TGF-beta1, TGFB, TGFbeta.
Associated Diseases
- Cystic fibrosis
- Inflammatory bowel disease, immunodeficiency, and encephalopathy
- Camurati-Engelmann disease
- Idiopathic pulmonary fibrosis
