TGDS
Description
The TGDS gene, located on chromosome 11, encodes for the enzyme triacylglycerol diacylglycerol acyltransferase, also known as DGAT2. This enzyme plays a crucial role in the final step of triglyceride synthesis, converting diacylglycerol to triacylglycerol. Triglycerides are the primary form of energy storage in humans and are also essential for cell membrane structure and function. TGDS gene mutations can disrupt this crucial metabolic pathway, leading to various health consequences.
Associated Diseases
- Congenital Generalized Lipodystrophy Type 2 (Berardinelli-Seip syndrome)
- Hypertriglyceridemia
- Insulin Resistance
- Fatty Liver Disease
- Cardiovascular Disease
Did you know?
Mutations in the TGDS gene are associated with a rare genetic disorder called Congenital Generalized Lipodystrophy Type 2, which causes a complete absence of body fat, leading to severe health complications.
