TBX15
Description
The TBX15 (T-box transcription factor 15) is a protein-coding gene located on chromosome 1.
The human TBX15 gene encodes the T-box transcription factor TBX15 protein. Located on chromosome 1, TBX15 plays a vital role in embryonic development. Like other T-box family members, it's expressed in the notochord and primitive streak, contributing to mesoderm formation and differentiation. Its expression declines after paraxial mesoderm segmentation. The T-box family is essential for embryo viability, with TBX15 contributing to skeletal development. Heterozygous TBX15 mutations in mice lead to short tails and sacral vertebrae defects, while homozygous mutations result in severe mesodermal development abnormalities, including a shortened body axis, notochord failure, and lack of posterior somite development. Embryos lacking TBX15 die around day 10 due to allantois formation failure. While TBX15 plays a significant role in development, its contribution within the T-box family is considered relatively minor.
TBX15 is a probable transcriptional regulator involved in the development of the skeleton, specifically the limbs, vertebral column, and head. It influences the number of mesenchymal precursor cells and chondrocytes, ultimately impacting bone development.
TBX15 is also known as TBX14.
