TBC1D23
Description
The TBC1D23 (TBC1 domain family member 23) is a protein-coding gene located on chromosome 3.
TBC1D23, also known as HCV non-structural protein 4A-transactivated protein 1, is a putative Rab GTPase-activating protein that plays a role in vesicular trafficking. It is involved in endosome-to-Golgi trafficking and acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with the WDR11 complex, it facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including cortical neuron positioning. It may also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, two processes that are essential for axonal and dendritic growth. Additionally, TBC1D23 may act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. It does not alter initial activation events but instead affects the maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge.
TBC1D23 is also known as NS4ATP1, PCH11.
