TAF6
Description
The TAF6 (TATA-box binding protein associated factor 6) is a protein-coding gene located on chromosome 7.
Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.
== Function == Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.
== Interactions == TAF6 has been shown to interact with:
TAF5 and TATA binding protein.
The TFIID complex is essential for initiating RNA polymerase II-dependent transcription, the process of copying DNA into RNA. It recognizes and binds to promoter regions on DNA, whether they contain a TATA box or not, through its TATA-box-binding protein (TBP) subunit. This binding helps to assemble the pre-initiation complex (PIC), a group of proteins necessary for transcription to begin. TFIID consists of TBP and a set of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12, and TAF13. The complex can be organized into three distinct modules: TFIID-A, TFIID-B, and TFIID-C. TAF6 plays a critical role in connecting these modules, forming a rigid core structure that holds the complex together.
TAF6 is also known as ALYUS, MGC:8964, TAF(II)70, TAF(II)80, TAF2E, TAFII-70, TAFII-80, TAFII70, TAFII80, TAFII85.
