TACR3

Description

The TACR3 gene, encodes the neurokinin-3 receptor (NK3R), a G protein-coupled receptor (GPCR) that plays a crucial role in various physiological processes. NK3R is primarily expressed in the central and peripheral nervous systems, particularly in the hypothalamus, amygdala, and brainstem, where it mediates the actions of neurokinin B (NKB), a neuropeptide involved in stress response, appetite regulation, and reproductive behavior. Additionally, NK3R is found on immune cells, suggesting its involvement in immune modulation.

Associated Diseases

• Anxiety disorders
• Depression
• Schizophrenia
• Bipolar disorder
• Eating disorders
• Asthma
• Irritable bowel syndrome
• Migraine
• Chronic pain
• Autoimmune diseases

Did you know?

Mutations in the TACR3 gene have been linked to variations in human personality traits, including impulsivity and aggression.