SUN5

Description

SUN5, located on chromosome 19, encodes a protein integral to the nuclear envelope, the membrane surrounding the cell's nucleus. This protein plays a crucial role in maintaining the structural integrity of the nuclear envelope, regulating nuclear transport, and ensuring proper chromosome segregation during cell division. Mutations in SUN5 are associated with a variety of human diseases, underscoring its critical role in cellular function.

Associated Diseases

• Emery-Dreifuss Muscular Dystrophy (EDMD)
• Dilated Cardiomyopathy (DCM)
• Autosomal Recessive Cerebellar Ataxia (ARCA)

Did you know?

SUN5 is a member of a family of proteins known as 'SUN domain proteins' that are found in all eukaryotic organisms, highlighting its evolutionary importance.