SUCLG1 : succinate-CoA ligase GDP/ADP-forming subunit alpha

Description

The SUCLG1 gene provides instructions for making a protein called succinyl-CoA ligase (ADP-forming), also known as succinyl-CoA synthetase. This enzyme plays a critical role in the citric acid cycle, a series of chemical reactions that generate energy for cells. Specifically, SUCLG1 catalyzes the conversion of succinyl-CoA to succinate, producing ATP (adenosine triphosphate), the primary energy currency of cells. Mutations in the SUCLG1 gene can disrupt this process, leading to various metabolic disorders.

Associated Diseases

• Succinyl-CoA ligase deficiency
• Mitochondrial respiratory chain disorders
• Leigh syndrome
• Global developmental delay
• Neurological disorders

Did you know?

The SUCLG1 gene is located on chromosome 17, a large chromosome that contains a significant number of genes important for various biological functions.