STAR
Description
The STAR gene, also known as the ‘steroidogenic acute regulatory protein‘ gene, plays a crucial role in the production of steroid hormones. It encodes a protein that facilitates the movement of cholesterol, the precursor to steroid hormones, from the outer mitochondrial membrane to the inner mitochondrial membrane, where the process of steroidogenesis takes place. This vital step is essential for the synthesis of essential hormones like testosterone, estrogen, progesterone, and cortisol, which are involved in a wide range of physiological functions including sexual development, stress response, and metabolism.
Associated Diseases
- Lipoid Congenital Adrenal Hyperplasia (LCAH): A rare genetic disorder characterized by a deficiency in steroid hormone production due to mutations in the STAR gene.
- Adrenal insufficiency: Insufficient production of adrenal hormones can lead to fatigue, weight loss, and low blood pressure.
- Infertility: In both males and females, disruptions in steroid hormone production due to STAR gene mutations can contribute to infertility.
- Premature ovarian failure: This condition involves the premature cessation of ovarian function, often associated with mutations in the STAR gene.
Did you know?
The STAR protein is a fascinating example of how a single protein can have a profound impact on the body‘s hormonal balance.
