STAMBP : STAM binding protein
Description
The STAMBP (STAM binding protein) is a protein-coding gene located on chromosome 2.
The STAMBP gene provides instructions for making a protein called STAM binding protein. While its exact function is not fully understood, within cells, this protein interacts with large groups of interrelated proteins known as endosomal sorting complexes required for transport (ESCRTs). ESCRTs aid in transporting proteins from the outer cell membrane to the cell's interior, a process known as endocytosis. Notably, they are involved in the endocytosis of damaged or unneeded proteins that require breakdown (degradation) or recycling by the cell. ESCRTs help sort these proteins into structures called multivesicular bodies (MVBs), which deliver them to lysosomes. Lysosomes are compartments within cells that digest and recycle numerous types of molecules. Through its association with ESCRTs, STAM binding protein helps maintain the proper balance of protein production and breakdown (protein homeostasis) that cells need to function and survive. Studies indicate that the interaction of STAM binding protein with ESCRTs is also involved in multiple chemical signaling pathways within cells, including pathways essential for overall growth and the formation of new blood vessels (angiogenesis).
STAMBP is a zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. It does not cleave 'Lys-48'-linked polyubiquitin chains. STAMBP plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. It potentiates BMP signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. STAMBP has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. STAMBP is involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
STAMBP is also known as AMSH, MICCAP.
