STAG3
Description
The STAG3 (STAG3 cohesin complex component) is a protein-coding gene located on chromosome 7.
STAG3 is a protein that is crucial for the proper separation of sister chromatids during meiosis. It is a part of the cohesin complex, which plays a vital role in holding sister chromatids together throughout meiosis. STAG3 interacts with various structures during meiosis, including the synaptonemal complex (SC), axial elements, centromeres, and telomeres. This involvement suggests that STAG3 is essential for sister-chromatid cohesion and potentially also for telomere cohesion. STAG3's role in the cohesin complex shifts as meiosis progresses, with its function changing after prophase.
STAG3 is a component of the meiosis-specific cohesin complex, which is essential for holding sister chromatids together after DNA replication. This complex forms a ring-like structure that encircles the sister chromatids, keeping them attached. During anaphase, the complex is broken down, releasing the sister chromatids so they can separate. STAG3's role is particularly important in prophase I of meiosis, where it likely replaces the mitosis-specific cohesin complex.
STAG3 is also known as SA3, SPGF61.
Associated Diseases
- Premature ovarian failure 8
- Male infertility with azoospermia or oligozoospermia due to single gene mutation
- Spermatogenic failure 61
