ST14

Description

The ST14 gene, also known as the urokinase-type plasminogen activator receptor (uPAR) gene, encodes a protein that plays a crucial role in various biological processes, including cell migration, tissue remodeling, and inflammation. uPAR is a transmembrane protein that binds to the enzyme plasminogen activator, initiating a cascade of events leading to the breakdown of fibrin clots and the activation of various signaling pathways. Its intricate involvement in cellular communication and tissue homeostasis makes ST14 a key regulator of immune responses and inflammatory processes.

Associated Diseases

• Cancer (e.g., breast cancer, prostate cancer, colorectal cancer)
• Cardiovascular diseases (e.g., atherosclerosis, heart attack)
• Autoimmune diseases (e.g., rheumatoid arthritis, lupus)
• Inflammatory bowel disease
• Neurodegenerative diseases (e.g., Alzheimer‘s disease, Parkinson‘s disease)

Did you know?

ST14 expression is often elevated in cancer cells, contributing to their ability to invade surrounding tissues and metastasize.