SPAG17

Description

SPAG17, also known as sperm-associated antigen 17, is a gene that plays a crucial role in the formation and function of the sperm flagellum, the tail-like structure that propels sperm towards the egg. It encodes a protein that interacts with other proteins involved in microtubule assembly, which are the building blocks of the flagellum. Mutations in SPAG17 can disrupt flagellar formation and lead to male infertility, highlighting its importance in male reproductive health.

Associated Diseases

• Male infertility
• Asthenozoospermia (reduced sperm motility)
• Teratozoospermia (abnormal sperm morphology)

Did you know?

SPAG17 is highly conserved across different species, suggesting its fundamental role in sperm motility.