SMARCD2
Description
The SMARCD2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2) is a protein-coding gene located on chromosome 17.
SMARCD2, encoded by the SMARCD2 gene, is a protein belonging to the SWI/SNF family. Members of this family have helicase and ATPase activities, suggesting their role in regulating gene transcription by altering chromatin structure. SMARCD2 is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and shares sequence similarity with the yeast protein Swp73.
SMARCD2 is involved in regulating the expression of genes by altering the structure of chromatin, the complex of DNA and proteins that makes up chromosomes. It does this by being a component of SWI/SNF chromatin remodeling complexes, which use ATP to change how DNA is packaged within the nucleosome. This can activate or repress gene expression, depending on the specific gene and the context. SMARCD2 plays a critical role in myeloid differentiation, a process where stem cells become various types of white blood cells. It specifically controls granulocytopoiesis, the formation of granulocytes, a type of white blood cell, and regulates the expression of genes involved in the formation of neutrophil granules, which are important for fighting infections.
SMARCD2 is also known as BAF60B, CRACD2, PRO2451, Rsc6p, SGD2.
