SLC37A4 : solute carrier family 37 member 4
Description
SLC37A4, also known as the glucose-6-phosphate transporter 1 (G6PT1), is a vital gene responsible for transporting glucose-6-phosphate (G6P) across cellular membranes. This intricate process plays a critical role in maintaining glucose homeostasis by regulating glycolysis, glycogen synthesis, and gluconeogenesis. SLC37A4 is primarily expressed in the liver, kidneys, and pancreas, reflecting its involvement in these metabolically active organs. The gene‘s role in transporting G6P across the endoplasmic reticulum membrane is crucial for maintaining the intricate balance of glucose metabolism within cells.
Associated Diseases
- Type 2 Diabetes Mellitus (T2DM): Mutations in SLC37A4 have been linked to increased risk of developing T2DM.
- Non-alcoholic fatty liver disease (NAFLD): Aberrant SLC37A4 activity is associated with NAFLD progression.
- Glycogen Storage Disease Type 1b (GSD1b): Deficiency in SLC37A4 activity leads to GSD1b, a rare genetic disorder characterized by glycogen accumulation in the liver and other tissues.
Did you know?
SLC37A4 is a crucial player in the complex interplay between glucose metabolism and lipid metabolism, highlighting the interconnected nature of these vital processes within the body.
