SLC30A10 : solute carrier family 30 member 10

Description

The SLC30A10 gene encodes a protein called zinc transporter 10 (ZnT10), a crucial component of the body‘s zinc transport system. ZnT10 acts as a zinc efflux transporter, shuttling zinc ions out of cells and into specific compartments. This process is critical for maintaining proper zinc levels within cells and tissues, which is essential for a wide range of physiological functions. Zinc plays a vital role in immune function, wound healing, growth and development, and enzymatic activity. Dysregulation of zinc homeostasis due to SLC30A10 gene mutations can lead to various health complications.

Associated Diseases

• Acrodermatitis enteropathica (AE): An autosomal recessive disorder characterized by severe zinc deficiency, leading to skin lesions, hair loss, diarrhea, and impaired growth.
• Zinc deficiency: While not directly linked to SLC30A10 mutations, zinc deficiency can arise from inadequate dietary intake or impaired absorption, impacting overall health.
• Neurodevelopmental disorders: Research suggests a potential link between SLC30A10 gene variations and certain neurodevelopmental conditions, but further investigation is needed.
• Cancer: Some studies indicate a possible role of ZnT10 in cancer development and progression, highlighting the importance of zinc homeostasis in cell growth and proliferation.

Did you know?

ZnT10 is primarily expressed in the intestines, suggesting its role in zinc absorption and distribution throughout the body.