SLC2A9 : solute carrier family 2 member 9
Description
SLC2A9, also known as GLUT9, is a gene that encodes a protein involved in the transport of glucose and fructose across cell membranes. This transporter plays a crucial role in maintaining glucose homeostasis, particularly in the liver, kidney, and intestine. SLC2A9 is highly expressed in these tissues, contributing to the regulation of glucose uptake and release, as well as fructose metabolism. Additionally, SLC2A9 has been implicated in various physiological processes, including insulin sensitivity, lipid metabolism, and cancer development.
Associated Diseases
- Type 2 Diabetes Mellitus: Altered SLC2A9 expression has been linked to insulin resistance and the development of type 2 diabetes.
- Non-alcoholic Fatty Liver Disease (NAFLD): Mutations in SLC2A9 have been associated with an increased risk of NAFLD, suggesting its role in liver fat accumulation.
- Cancer: Studies have indicated a potential association between SLC2A9 expression levels and cancer progression in various types of cancer.
- Fructose Malabsorption: In certain individuals, SLC2A9 mutations can lead to impaired fructose absorption, resulting in gastrointestinal symptoms.
Did you know?
SLC2A9 exhibits a unique characteristic of transporting both glucose and fructose, making it a bifunctional transporter.
