SLC25A21
Description
SLC25A21, also known as the mitochondrial dicarboxylate carrier (DIC), is a transmembrane protein responsible for transporting dicarboxylic acids across the inner mitochondrial membrane. These dicarboxylates include substrates such as malate, succinate, and fumarate, crucial for the citric acid cycle and oxidative phosphorylation, the main energy-producing pathway in cells. SLC25A21 plays a vital role in maintaining mitochondrial function, energy metabolism, and cellular homeostasis. Its dysfunction has been linked to various metabolic disorders, emphasizing its importance in human health.
Associated Diseases
Did you know?
Mutations in SLC25A21 have been linked to a rare genetic disorder called "dicarboxylate transporter deficiency," characterized by lactic acidosis, developmental delays, and neurological problems.
