SLC22A12 : solute carrier family 22 member 12

Description

The SLC22A12 gene encodes an organic anion transporter protein (OATP1B3) that plays a crucial role in drug metabolism and disposition. Located on chromosome 2, SLC22A12 facilitates the uptake of various substrates, including bilirubin, steroid hormones, and a wide range of medications, from the bloodstream into hepatocytes. This process is vital for drug efficacy and elimination, influencing the pharmacokinetic properties of numerous drugs. Variations in SLC22A12 expression or function can lead to altered drug responses and increased risk of adverse drug events.

Associated Diseases

• Drug-induced liver injury (DILI)
• Hyperbilirubinemia
• Gilbert‘s syndrome
• Crigler-Najjar syndrome
• Drug resistance
• Adverse drug reactions

Did you know?

Genetic variations in SLC22A12 are linked to individual differences in drug response, explaining why some people experience greater side effects or require higher doses compared to others.