SLC11A2 : solute carrier family 11 member 2

Description

The SLC11A2 gene, also known as the natural resistance-associated macrophage protein 1 (NRAMP1) gene, plays a crucial role in the innate immune response. It encodes a divalent metal transporter responsible for iron and manganese uptake in macrophages, cells that engulf and destroy pathogens. This transporter activity is critical for macrophages to activate their antimicrobial defenses, including the production of reactive oxygen species and nitric oxide. Variations in the SLC11A2 gene can influence susceptibility to various infectious diseases, highlighting its importance in maintaining immune homeostasis.

Associated Diseases

• Tuberculosis
• Leprosy
• Salmonella enterica infection
• Crohn‘s disease
• Inflammatory bowel disease
• Iron deficiency anemia

Did you know?

Mutations in the SLC11A2 gene have been linked to increased susceptibility to infections in humans and animals, highlighting the importance of this gene in fighting off pathogens.