SERPINE1

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Description

The SERPINE1 gene encodes plasminogen activator inhibitor-1 (PAI-1), a crucial protein involved in regulating coagulation and fibrinolysis. PAI-1 inhibits the activity of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), preventing the breakdown of fibrin clots and promoting thrombus formation. SERPINE1 plays a critical role in maintaining hemostasis and wound healing, but its dysregulation can contribute to various cardiovascular and thrombotic disorders.

Associated Diseases

• Venous thromboembolism (VTE)
• Coronary artery disease (CAD)
• Stroke
• Cancer
• Diabetes
• Obesity
• Metabolic syndrome

Did you know?

PAI-1 levels are influenced by various factors, including age, sex, lifestyle, and genetic predisposition.