SERPINA6 : serpin family A member 6
Description
The SERPINA6 (serpin family A member 6) is a protein-coding gene located on chromosome 14.
The SERPINA6 gene provides instructions for making a protein called corticosteroid-binding globulin (CBG), which is primarily produced in the liver. CBG binds to cortisol, a hormone with various functions such as maintaining blood glucose levels, protecting the body from stress, and suppressing inflammation. When bound to CBG, cortisol becomes inactive. Normally, 80-90% of the body's cortisol is bound to CBG, 5-10% is unbound and active, and the remaining is bound to albumin. CBG delivers cortisol to tissues when needed, releasing it and activating the hormone. This process regulates the amount of active cortisol available in the body. The total cortisol in the body comprises both bound (inactive) and unbound (active) forms.
SERPINA6 encodes for Corticosteroid-binding globulin (CBG), which serves as the primary transport protein for glucocorticoids and progestins in the blood of nearly all vertebrate species.
SERPINA6 is also known as CBG.
