SBDS : SBDS ribosome maturation factor
Description
The SBDS (SBDS ribosome maturation factor) is a protein-coding gene located on chromosome 7.
The SBDS gene provides instructions for making a protein that is critical for building ribosomes. Ribosomes are cellular structures that process the cell's genetic instructions to create proteins. Each ribosome is made up of two parts (subunits) called the large subunit and the small subunit. The SBDS protein helps prepare the large subunit so it can assemble into the ribosome by helping remove another protein (called eIF6) that blocks the interaction of the large subunit with the small subunit.Research suggests that the SBDS protein may be involved in other cellular processes, such as ensuring proper cell division, aiding cell movement, protecting cells from stress, and processing RNA, a molecule that is a chemical cousin of DNA. More research is needed to clarify the protein's role in these processes.
SBDS is essential for the assembly of mature ribosomes and ribosome biogenesis. It works in conjunction with EFL1 to trigger the release of EIF6 from 60S pre-ribosomes in the cytoplasm, a process driven by GTP. This activation of ribosomes allows for translation competence by enabling 80S ribosome assembly. The process also facilitates EIF6 recycling back to the nucleus, where it's needed for 60S rRNA processing and nuclear export. SBDS is crucial for maintaining normal protein synthesis levels and may contribute to cellular stress resistance, DNA damage response, and cell proliferation.
SBDS is also known as CGI-97, SDO1, SDS, SWDS.
