ROR2 : receptor tyrosine kinase like orphan receptor 2
Description
The ROR2 (receptor tyrosine kinase like orphan receptor 2) is a protein-coding gene located on chromosome 9.
The ROR2 gene provides instructions for making a protein whose function is not fully understood. The ROR2 protein belongs to a family of proteins called receptor tyrosine kinases (RTKs) that play a role in chemical signaling within cells. RTKs are involved in many cellular functions, including cell growth and division, cell maturation, cell survival, and cell movement. Researchers believe that the ROR2 protein plays a vital role in development starting before birth. It is involved in Wnt signaling pathways, which affect many developmental aspects. These pathways control the activity of genes required at specific times and regulate cell interactions during organ and tissue formation. Specifically, the ROR2 protein appears to be crucial for the normal development of the skeleton, heart, and genitals.
ROR2 is a tyrosine-protein kinase receptor that may play a role in the early development of chondrocytes. It appears to be essential for the growth and development of cartilage and the growth plate. ROR2 phosphorylates YWHAB, which triggers osteogenesis and bone formation. However, it has also been shown to exhibit minimal tyrosine kinase activity in laboratory settings. ROR2 may act as a receptor for the Wnt ligand WNT5A, potentially leading to the suppression of WNT3A-mediated signaling.
ROR2 is also known as BDB, BDB1, NTRKR2.
Associated Diseases
- Brachydactyly, type B1
- Autosomal recessive Robinow syndrome
- Robinow syndrome, autosomal recessive
- Robinow syndrome
