ROR1
Description
The ROR1 (receptor tyrosine kinase like orphan receptor 1) is a protein-coding gene located on chromosome 1.
ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is a protein encoded by the ROR1 gene in humans. It belongs to the receptor tyrosine kinase-like orphan receptor (ROR) family and acts as a receptor tyrosine kinase that regulates neurite growth in the central nervous system. This type I membrane protein is currently being investigated for its potential role in cancer cell metastasis. ROR1 has been found to be expressed on ovarian cancer stem cells, where it contributes to migration, invasion, spheroid formation in vitro, and tumor engraftment in immune-deficient mice. Treatment with a humanized monoclonal antibody (UC-961) targeting ROR1 inhibits these processes and reduces the growth of tumor xenografts, suggesting its potential for anti-cancer stem cell therapy. Additionally, Zilovertamab vedotin (ZV), an antibody-drug conjugate targeting ROR1, is currently in clinical trials for treating lymphoid malignancies.
ROR1 is also known as NTRKR1, dJ537F10.1.
