RNASET2 : ribonuclease T2
Description
The RNASET2 (ribonuclease T2) is a protein-coding gene located on chromosome 6.
The RNASET2 gene provides instructions for making a protein called ribonuclease T2 (RNAse T2), which is abundant in the brain. Ribonucleases help break down RNA, a chemical cousin of DNA. Studies suggest that ribonuclease T2 may also be involved in other functions within cells, such as controlling the development of blood vessels (angiogenesis) and helping to prevent the growth of cancerous tumors. These potential roles of the protein are not well understood.
RNASET2 encodes ribonuclease T2, a protein that plays a crucial role in the innate immune response by recognizing and degrading RNAs from microbial pathogens. This degradation is sensed by TLR8, leading to an immune response. RNASET2 preferentially cleaves single-stranded RNA molecules between purine and uridine residues, contributing to uridine supply and the production of specific oligoribonucleotides. These degradation products activate TLR8, further boosting the immune response. RNASET2 is also essential for the degradation of mitochondrial RNA and the processing of non-coding RNA imported into mitochondria. It participates in the degradation of mitochondrion-associated cytosolic rRNAs.
RNASET2 is also known as RNASE6PL, bA514O12.3.
