RIPOR2
Description
The RIPOR2 (RHO family interacting cell polarization regulator 2) is a protein-coding gene located on chromosome 6.
RIPOR2 is a protein encoded by the RIPOR2 gene. It stimulates the formation of a non-mitotic multinucleate syncytium from proliferative cytotrophoblasts during trophoblast differentiation. Mutations in RIPOR2 are associated with hearing loss.
RIPOR2 acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation, and neutrophil polarization. RIPOR2 inhibits chemokine-induced T lymphocyte responses such as cell adhesion, polarization, and migration. It is also involved in the regulation of neutrophil polarization, chemotaxis, and adhesion. RIPOR2 is required for the normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear and plays a role in maintaining the structural organization of the basal domain of stereocilia. RIPOR2 is involved in mechanosensory hair cell function and is required for normal hearing.
RIPOR2 is also known as C6orf32, DFNA21, DFNB104, DIFF40, DIFF48, FAM65B, MYONAP, PL48.
