RET

The RET gene builds a protein involved in cell signaling pathways critical for development and cell growth control. This protein acts like a cellular messenger, normally relaying signals that instruct cells to grow, differentiate, and mature. Mutations in the RET gene can lead to the production of a constantly active RET protein, promoting uncontrolled cell growth and potentially contributing to cancer development.

Associated Diseases

Medullary thyroid carcinoma, Papillary thyroid carcinoma,Hirschsprung Disease, Multiple endocrine neoplasia (type 2)

Did you know

RET alterations are detected in a small percentage (around 2-3%) of various cancers, including lung adenocarcinoma, colon adenocarcinoma, and thyroid cancers (source: NCCN).