RELN : reelin
Description
The RELN gene, located on chromosome 7, encodes the protein Reelin, a crucial molecule in the development and proper functioning of the brain. Reelin plays a vital role in neuronal migration, axonal guidance, and synapse formation during brain development. It is secreted by Cajal-Retzius cells in the developing cortex and helps to organize the layers of the cerebral cortex. Mutations in the RELN gene can disrupt these processes, leading to various neurological disorders.
Associated Diseases
Did you know?
Reelin was initially discovered in mice with a ‘reeler‘ phenotype, characterized by a wobbly gait and a distinctly disorganized brain structure.
