RBL2
Description
The RBL2 (RB transcriptional corepressor like 2) is a protein-coding gene located on chromosome 16.
Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Retinoblastoma-like protein 2 has been shown to interact with: Pocket protein family
RBL2 plays a crucial role in regulating the transition into cell division. It directly participates in the formation of heterochromatin, a tightly packed form of DNA, by maintaining the overall structure of chromatin and particularly by stabilizing histone methylation. It interacts with and recruits histone methyltransferases KMT5B and KMT5C, leading to epigenetic silencing of genes. RBL2 controls the trimethylation of histone H4 at lysine 20, a key modification associated with heterochromatin. It likely functions as a transcription repressor by recruiting chromatin-modifying enzymes to gene promoters. RBL2 potently inhibits the activation of genes by the E2F transcription factors, particularly E2F5. Furthermore, it interacts with cyclins A and E, proteins that regulate the cell cycle. RBL2 can bind to the adenovirus E1A protein, a viral protein involved in cell transformation, suggesting a possible role in viral infection. Due to its involvement in cell cycle regulation and its ability to interact with proteins involved in cancer development, RBL2 is believed to have tumor suppressor activity.
RBL2 is also known as BRUWAG, P130, Rb2.
