PTPRQ
Description
The PTPRQ (protein tyrosine phosphatase receptor type Q) is a protein-coding gene located on chromosome 12.
PTPRQ is a receptor tyrosine phosphatase, a type of enzyme-linked receptor phosphatase belonging to a larger family of protein tyrosine phosphatases in humans. This family also includes PTPRA, PTPRB, PTPRC, PTPRD, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN, PTPRN2, PTPRO, PTPRR, PTPRS, PTPRT, PTPRU, and PTPRZ phosphatases.
PTPRQ is a phosphatidylinositol phosphatase that is crucial for auditory function. It likely regulates the levels of phosphatidylinositol 4,5-bisphosphate (PIP2) in the base of hair bundles, potentially influencing hair cell function. PTPRQ has a broad substrate range, capable of dephosphorylating a variety of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate, monophosphates, and diphosphates. Its activity extends to both the D3 and D5 positions of the inositol ring. While it demonstrates low tyrosine-protein phosphatase activity, the significance of this in biological systems remains unclear. PTPRQ plays a significant role in the development of adipocytes from mesenchymal stem cells (MSCs). It regulates the phosphorylation state of AKT1 by controlling PIP3 levels in MSCs and preadipocyte cells.
PTPRQ is also known as DFNA73, DFNB84, DFNB84A, PTPGMC1, R-PTP-Q.
