PTPRO
Description
The PTPRO gene, located on chromosome 12, encodes a protein tyrosine phosphatase known as protein tyrosine phosphatase, receptor type O. This enzyme plays a critical role in regulating cell signaling pathways by removing phosphate groups from tyrosine residues on proteins. This dephosphorylation process is essential for controlling various cellular functions, including cell growth, differentiation, migration, and survival. PTPRO‘s activity is tightly regulated, and its dysregulation has been linked to several diseases, underscoring its importance in maintaining cellular homeostasis.
Associated Diseases
- Cancer (breast, prostate, lung, colorectal)
- Neurodevelopmental disorders (autism spectrum disorder, intellectual disability)
- Cardiovascular diseases (atherosclerosis, hypertension)
- Inflammatory diseases (rheumatoid arthritis, inflammatory bowel disease)
Did you know?
PTPRO is highly expressed in the brain and plays a crucial role in neuronal development and function.
