PTPN14

Description

The PTPN14 gene, encodes a protein tyrosine phosphatase (PTP) that plays a crucial role in regulating various cellular processes, including immune responses, cell growth, and development. PTPN14 is a transmembrane protein with both intracellular and extracellular domains, allowing it to interact with a wide range of signaling molecules. Its primary function involves dephosphorylating tyrosine residues on target proteins, thereby modulating their activity and downstream signaling pathways. The intricate interplay between PTPN14 and these pathways contributes to its diverse roles in physiological and pathological contexts.

Associated Diseases

• Autoimmune diseases (e.g., systemic lupus erythematosus, rheumatoid arthritis)
• Cancer (e.g., leukemia, lymphoma, breast cancer)
• Neurological disorders (e.g., Alzheimer‘s disease, Parkinson‘s disease)

Did you know?

PTPN14 has been implicated in the development of autoimmune diseases by its role in regulating the activity of T cells, a type of immune cell that plays a critical role in immune responses.